– Mastocytosis, Idiopathic Mast Cell Activation Syndrome (MCAS)
Seminal Plasma Hypersensitivity

Allergic reactions to human seminal plasma (HSP) or male semen may present with either localized-vaginal reactions, systemic-allergic reactions (including anaphylaxis), or both. While HSP allergy is rare, it may be underreported because of the socially-sensitive nature of the problem or misdiagnosed as vulvovaginitis. This disorder occurs exclusively in women, most typically between the ages of 20 and 30 years of age. Signs and symptoms begin shortly after ejaculation, typically during or immediately following the completion of intercourse.

If you believe you are suffering from allergic reactions to seminal plasma, then the physicians at the Bernstein Allergy Group might have an alternative approach that could work for you. After a thorough clinical history and investigation into other possible causes including latex allergy, the diagnosis of HSP sensitivity will be made using skin prick tests to whole seminal plasma or allergen-containing fractions of HSP in our office. While most symptoms can be prevented by the use of condoms, for women who find condom use unacceptable or wish to conceive naturally, we suggest HSP desensitization using either intra-vaginal or subcutaneous protocols.

– Progesterone Hypersensitivity: https://pubmed.ncbi.nlm.nih.gov/29349660/
– Chronic Vulvovaginal Candida Hypersensitivity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388876/
– Dysautonomia

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