Angioedema (sudden swelling under the skin)
Angioedema or "soft tissue swelling" occurs as the result of fluid accumulation in the deeper dermis. Angioedema occurs by itself in 20% of cases and in conjunction with hives in 40% of cases. Isolated angioedema can often be seen as a result of certain medication reactions such as ACE inhibitor blood pressure medications or aspirin and/or non-steroidal anti-inflammatory medications (advil, alleve…). Isolated angioedema is also seen in patients who have rarer conditions called hereditary and acquired angioedema. Patient with hereditary angioedema have either a decreased amount of C1esterase inhibitor or functionally abnormal levels. This enzyme is important for regulating the production of a mediator called bradykinin that can cause swelling if there is too much in the body. The Bernstein Allergy Group has extensive experience in the evaluation, treatment and long term management of Isolated angioedema and angioedema occurring with hives. Recently several newer therapies for the treatment of hereditary angioedema have been approved by the Food Drug Administration for use in the United States. The Bernstein Allergy Group physicians have been involved in these trials and have extensive experience in the use of these novel treatments.
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